Table 1.
Sequence Traits and Neutrality Tests of Extreme Genes
| Gene | chromosome | ns | nf | pMWUhigh |
pHKAlow |
||
| AA | EA | AA | EA | ||||
| AA and EA | |||||||
| ADAM11 | 17 | 7 | 4 | 0.006 | 0.043 | 0.012 | 0.050 |
| ALPK2 | 18 | 39 | 31 | 0.026 | 0.028 | 0.000 | 0.000 |
| BTN1A1 | 6 | 7 | 5 | 0.012 | 0.030 | 0.028 | 0.036 |
| DEPDC2 | 8 | 7 | 4 | 0.048 | 0.028 | 0.025 | 0.018 |
| KRT14 [] | 17 | 10 | 6 | 0.004 | 0.007 | 0.005 | 0.003 |
| LGALS8 | 1 | 9 | 10 | 0.017 | 0.034 | 0.048 | 0.022 |
| LILRB4 [] | 19 | 8 | 4 | 0.009 | 0.000 | 0.006 | 0.002 |
| LINS1 | 15 | 15 | 14 | 0.031 | 0.008 | 0.020 | 0.019 |
| RCBTB1 | 13 | 11 | 6 | 0.007 | 0.017 | 0.003 | 0.001 |
| RPS7 | 2 | 10 | 1 | 0.003 | 0.003 | 0.000 | 0.000 |
| RTP4 | 3 | 7 | 5 | 0.045 | 0.013 | 0.041 | 0.007 |
| TRIM22 | 11 | 9 | 5 | 0.047 | 0.038 | 0.004 | 0.008 |
| WDR40C [] | X | 7 | 3 | 0.034 | 0.036 | 0.006 | 0.003 |
| AA | |||||||
| ADAMTS7 | 15 | 7 | 3 | 0.047 | 0.107 | 0.007 | 0.025 |
| C14orf124 | 14 | 8 | 2 | 0.034 | 0.673 | 0.003 | 0.000 |
| CLCNKB [] | 1 | 16 | 18 | 0.024 | 0.407 | 0.011 | 0.205 |
| COL27A1 | 9 | 18 | 19 | 0.026 | 0.107 | 0.017 | 0.017 |
| COPE | 19 | 7 | 5 | 0.036 | 0.158 | 0.024 | 0.110 |
| FGF6 | 12 | 6 | 4 | 0.012 | 0.066 | 0.030 | 0.080 |
| FLJ40243 | 5 | 10 | 9 | 0.042 | 0.061 | 0.019 | 0.014 |
| KRT6B [] | 12 | 8 | 6 | 0.045 | 0.120 | 0.037 | 0.027 |
| KRT84 | 12 | 10 | 6 | 0.006 | 0.055 | 0.005 | 0.008 |
| LRRN6A | 15 | 8 | 3 | 0.028 | 0.101 | 0.008 | 0.003 |
| PPP1R15A | 19 | 15 | 14 | 0.008 | 0.145 | 0.028 | 0.003 |
| SERPINH1 [] | 11 | 7 | 3 | 0.041 | 0.106 | 0.013 | 0.003 |
| TARBP1 | 1 | 15 | 15 | 0.026 | 0.266 | 0.013 | 0.025 |
| TNS1 | 2 | 32 | 25 | 0.039 | 0.115 | 0.000 | 0.002 |
| TRPV6 [] | 7 | 10 | 11 | 0.021 | 0.410 | 0.035 | 0.030 |
| EA | |||||||
| ALDH4A1 | 1 | 10 | 5 | 0.141 | 0.035 | 0.015 | 0.002 |
| ARHGEF3 | 3 | 8 | 3 | 0.091 | 0.041 | 0.002 | 0.001 |
| C20orf186 | 20 | 12 | 9 | 0.072 | 0.025 | 0.009 | 0.003 |
| CAMK2B | 7 | 6 | 6 | 0.154 | 0.011 | 0.123 | 0.035 |
| CD200R1 | 3 | 5 | 5 | 0.016 | 0.015 | 0.159 | 0.050 |
| CDSN | 6 | 20 | 8 | 0.130 | 0.018 | 0.000 | 0.000 |
| FLJ90650 | 5 | 6 | 5 | 0.484 | 0.047 | 0.080 | 0.040 |
| FUT2 [] | 19 | 11 | 7 | 0.051 | 0.041 | 0.004 | 0.021 |
| GM632 | 20 | 9 | 12 | 0.407 | 0.037 | 0.334 | 0.044 |
| GPR111 | 6 | 6 | 5 | 0.009 | 0.018 | 0.080 | 0.020 |
| GRIN3A | 9 | 13 | 19 | 0.357 | 0.050 | 0.238 | 0.019 |
| HLA-B [] | 6 | 13 | 1 | 0.123 | 0.024 | 0.000 | 0.000 |
| KIAA0753 | 17 | 11 | 11 | 0.072 | 0.028 | 0.098 | 0.017 |
| KIAA1303 | 17 | 14 | 19 | 0.247 | 0.034 | 0.110 | 0.023 |
| KRT6E [] | 12 | 8 | 8 | 0.828 | 0.003 | 0.355 | 0.023 |
| LHB [] | 19 | 6 | 4 | 0.073 | 0.020 | 0.031 | 0.025 |
| LOC197322 | 16 | 10 | 14 | 0.004 | 0.016 | 0.095 | 0.047 |
| LRAP | 5 | 12 | 10 | 0.022 | 0.011 | 0.068 | 0.004 |
| MYO1G | 7 | 12 | 14 | 0.486 | 0.033 | 0.092 | 0.023 |
| NALP13 | 19 | 20 | 12 | 0.144 | 0.031 | 0.000 | 0.000 |
| PCDHB16 [] | 5 | 21 | 26 | 0.115 | 0.010 | 0.042 | 0.003 |
| RABEP1 | 17 | 9 | 9 | 0.126 | 0.030 | 0.061 | 0.036 |
| RIOK2 | 5 | 7 | 9 | 0.136 | 0.018 | 0.445 | 0.035 |
| SAMM50 | 22 | 9 | 5 | 0.118 | 0.045 | 0.009 | 0.004 |
| SERPINB5 | 18 | 8 | 4 | 0.130 | 0.042 | 0.010 | 0.015 |
| SLC2A9 | 4 | 7 | 3 | 0.068 | 0.017 | 0.006 | 0.003 |
| SMARCAD1 | 4 | 8 | 4 | 0.662 | 0.048 | 0.013 | 0.006 |
| TMEM171 | 5 | 6 | 4 | 0.096 | 0.016 | 0.118 | 0.024 |
| TSPAN10 | 17 | 10 | 4 | 0.106 | 0.021 | 0.011 | 0.000 |
| UNC5C | 4 | 10 | 13 | 0.419 | 0.046 | 0.240 | 0.035 |
| VARSL | 6 | 14 | 6 | 0.055 | 0.013 | 0.000 | 0.000 |
| ZNF415 [] | 19 | 10 | 6 | 0.088 | 0.022 | 0.008 | 0.018 |
NOTE.—ns: number of segregating sites; and nf: number of fixed divergent sites (human vs. chimpanzee). pMWUhigh: P value of MWUhigh test in AA or EA. pHKAlow: P value of HKAlow test in AA or EA. Bolded genes are considered population-specific because they show P value >0.2 for at least one test in the other population. Genes marked with [] represent cases where events of gene conversion could not be completely discarded. Full names of all genes are shown in supplementary table 1 (Supplementary Material online).