Figure 4.

Time-dependent effects of i.v.-injected vehicle and tegaserod (1 mg·kg⁻¹) on mesenteric blood flow (MBF, left panels) and mesenteric vascular conductance (MVC, right panels) in fasted (A,B) and non-fasted (C,D) rats. The basal values of the cardiovascular parameters were recorded and averaged during the 25–10 min period pre injection and set as 100%. The values recorded and averaged during the 5–20 min, 35–50 min, 95–110 min and 125–140 min periods post injection are expressed as a percentage of the baseline recordings. Means ± SEM, n= 7–12. *P < 0.05, **P < 0.01 versus basal (one-way anova for repeated measures followed by the Bonferroni test); +P < 0.05, ++P < 0.01 versus vehicle (Student's t-test).