Table 1.
Baseline values of cardiovascular parameters
| Cardiovascular parameter | Study 1: fasted rats | Study 2: fasted rats | Study 2: non-fasted rats | Study 3: fasted rats | Study 4: fasted rats |
|---|---|---|---|---|---|
| MAP (mmHg) | 94.7 ± 1.5 (90) | 84.0 ± 1.4 (85) | 86.5 ± 2.8 (22) | 88.2 ± 1.9 (38) | 81.8 ± 3.6 (21) |
| HR (beats·min−1) | 342 ± 7.2 (81) | 346 ± 7.2 (85) | 357 ± 14.6 (18) | 362 ± 7.1 (38) | 333 ± 12.3 (21) |
| MBF (mL·min−1) | 14.8 ± 0.54 (90) | 12.6 ± 0.31 (85) | 17.4 ± 1.0 (22)** | 13.0 ± 0.45 (38) | 15.7 ± 0.90 (21) |
| MVC [µl·min−1·(mmHg)−1] | 159 ± 6.5 (90) | 153 ± 4.9 (85) | 209 ± 16.2 (22)** | 150 ± 6.5 (38) | 200 ± 13.6 (21) |
| CBFa[mL·min−1·(100 g)−1] | 92.2 ± 4.4 (88) | N.M. | N.M. | N.M. | N.M. |
| CVCa[mL·min−1·(100 g)−1·(mmHg)−1] | 1.0 ± 0.06 (88) | N.M. | N.M. | N.M. | N.M. |
a
CBF and CVC were measured by the hydrogen gas clearance technique. The cardiovascular parameters were recorded immediately before administration of any drug or vehicle. Means ± SEM, n in parenthesis.
**
P < 0.01 versus respective values recorded in fasted rats of study 2 (Student's t-test).
CBF, colonic blood flow; CVC, colonic vascular conductance; HR, heart rate; MAP, mean arterial blood pressure; MBF, mesenteric blood flow; MVC, mesenteric vascular conductance; N.M., not measured.