Figure 1.

Effect of gly-rhAFP on the release of GM-CSF (A), IL-8 (B), MCP-1 (C) and IP-10 (D) by normal human keratinocytes, used alone in the dose range 10–200 µg·mL⁻¹, or in combination with 100 ng·mL⁻¹ TNF-α (T) or 100 U·mL⁻¹ IFN-γ (I). The results are expressed as the mean ± SD of three independent experiments. *P < 0.05 versus untreated controls (-) or versus stimulated controls (T or I). AFP, α-fetoprotein; gly-rhAFP, glycosylated recombinant human alpha fetoprotein; GM-CSF, granulocyte macrophage colony stimulating factor; IFN-γ, interferon gamma; IL, interleukin; IP-10, interferon gamma-produced protein of 10 kDa; MCP-1, monocyte chemotactic protein 1; TNF-α, tumour necrosis factor alpha.