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AFP alone induces TNF-α in purified CD4 T cells and boosts the release of IFN-γ (A) and TNF-α (B) due to CD3/CD28 stimulation. T lymphocytes were cultured in 24-well clusters and treated with rhAFP, in the presence or absence of CD3/CD28 stimulation. The results are representative of data obtained with CD4-positive T cells from six distinct blood donors. AFP, α-fetoprotein; IFN-γ, interferon gamma; rhAFP, recombinant human alpha fetoprotein; TNF-α, tumour necrosis factor alpha.
