Table 1.

Summary of single-channel kinetic analysis of the open time distributions from the α1β2γ2L receptor under control conditions, and in the presence of steroids

Agonist, modulator	OT1 (ms)	Fraction OT1	OT2 (ms)	Fraction OT2	OT3 (ms)	Fraction OT3	n
50 µM GABA	0.30 ± 0.06	0.20 ± 0.04	3.0 ± 0.6	0.67 ± 0.06	6.8 ± 2.9	0.13 ± 0.07	5
+1 µM 3α5αP	0.41 ± 0.04*	0.39 ± 0.07**	2.4 ± 0.9ns	0.23 ± 0.03***	14.1 ± 2.1*	0.38 ± 0.04*	4
+1 µM 3α5α18nor17βCN	0.24 ± 0.12ns	0.25 ± 0.14ns	2.6 ± 1.8ns	0.30 ± 0.09***	16.3 ± 4.4**	0.46 ± 0.10***	4
+3 µM 3α5αCDNC12	0.39 ± 0.09ns	0.35 ± 0.07ns	4.6 ± 3.6ns	0.25 ± 0.12***	16.5 ± 1.7**	0.40 ± 0.11***	4
+10 µM 3α5α17βEt	0.45 ± 0.11*	0.39 ± 0.03*	2.6 ± 1.2ns	0.22 ± 0.03***	17.0 ± 2.2**	0.39 ± 0.01***	4
+10 µM 3α5α17H	0.38 ± 0.03ns	0.39 ± 0.12*	1.5 ± 0.2ns	0.23 ± 0.12***	14.8 ± 4.3**	0.38 ± 0.05***	6

The intracluster open time histograms were fitted to a sum of three exponentials. The table gives the mean durations ± SD (OT1-3) and average relative contributions ± SD (fraction OT1-3) for the three open time components, and the number of patches under each condition (n). Statistical analysis was carried out using analysis of variance with Dunnett's correction (Systat 7.0, Systat Software, Inc., Point Richmond, CA, USA). The significance levels apply to comparison to control condition (50 µM GABA). The data for 3α5αP are from Akk et al. (2008).

^*P < 0.05;

^**P < 0.01;

^***P < 0.001; ns, not significant.