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. 2009 Sep 28;158(5):1338–1343. doi: 10.1111/j.1476-5381.2009.00400.x

Figure 1.

Figure 1

Whole-cell patch-clamp of cerebellar granule cells. (A) Typical response to (Z)-1-[2-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate (DETA-NONOate), showing the increase in baseline noise associated with the inward current. KCl depolarizations of similar magnitude did not elicit changes in baseline noise. (B) DETA-NONOate (n= 3) concentration response. The mean ± SEM values were: 10 µM, 0.0 ± 0; 100 µM, 0.06 ± 0.01; 300 µM, 0.103 ± 0.01; 1 mM, 0.30 ± 0.06; 10 mM, 1.0 ± 0.0. (C) S-nitrosoglutathione (n= 6) concentration response. The mean ± SEM values were: 100 µM, 0.0 ± 0.0; 1 mM, 0.12 ± 0.03; 3 mM 0.75 ± 0.06; 10 mM, 1.0 ± 0.0. All values were normalized to the response at 10 mM. Representative responses are shown to the right of each graph.