Figure 5.
Relation of trichloroethanol sensitivity to physicochemical parameters in N-methyl-d-aspartate (NMDA) receptors containing GluN2A(Ala825) mutant subunits. Graphs plot log IC50 for trichloroethanol (TCEt) versus molecular volume in Å3 (A), log octanol : water partition coefficient (Log P; B), hydrophilicity (C) and polarity (D) for the various substituents at GluN2A(Ala825). Data points are labelled with the substituted amino acid. The lines shown are the least-squares fits to the data. Log TCEt IC50 values were significantly linearly related to both hydrophilicity and polarity, but not molecular volume or Log P.