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. Author manuscript; available in PMC: 2009 Nov 25.
Published in final edited form as: J Hum Genet. 2009 Jul 24;54(9):516–524. doi: 10.1038/jhg.2009.71

Figure 2. POLG mutations in breast tumors and breast cancer cell lines.

Figure 2

A) Intron/Splice variants in the POLG genome; B) Mutations in the POLG protein with amino acid change. Green and red arrows indicate the novel variants and disease-associated mutations/polymorphisms, respectively. The grey and orange boxes indicate the novel silent and missense mutations, respectively; C) The amino acid conservation at the mutant residue of R628Q, a novel missense mutation observed in the linker region.