Table I.
Number of triads |
Risk haplotype frequency |
Pattern of missingness1 |
Mean total number of TT |
Mean number of triads with multiple TT |
Empirical coverage of nominal 95% CI |
Geometric mean of estimated R1 (95% CI)2 True |
---|---|---|---|---|---|---|
400 | 0.05 | None | 408.5 | 8.5 | 0.950 | 1.43(1.42,1.43) |
20% g | 901.4 | 199.5 | 0.945 | 1.43(1.42,1.44) | ||
20% g & 20% f | 4104.1 | 241.2 | 0.946 | 1.43(1.42,1.44) | ||
0.142 | None | 411.1 | 11.0 | 0.950 | 1.42(1.41,1.42) | |
20% g | 905.9 | 200.8 | 0.951 | 1.42(1.41,1.42) | ||
20% g & 20% f | 4141.3 | 242.2 | 0.951 | 1.42(1.41,1.43) | ||
0.25 | None | 412.8 | 12.7 | 0.948 | 1.42(1.41,1.42) | |
20% g | 904.6 | 200.8 | 0.947 | 1.42(1.41,1.42) | ||
20% g & 20% f | 4196.8 | 241.9 | 0.948 | 1.42(1.41,1.42) | ||
0.4 | None | 412.4 | 12.2 | 0.949 | 1.41(1.41,1.42) | |
20% g | 885.6 | 197.1 | 0.948 | 1.41(1.41,1.42) | ||
20% g & 20% f | 4212.6 | 238.4 | 0.947 | 1.41(1.41,1.42) | ||
1000 | 0.02 | None | 1018.6 | 18.5 | 0.942 | 1.43(1.42,1.43) |
20% g | 2226.7 | 491.9 | 0.945 | 1.43(1.42,1.44) | ||
20% g & 20% f | 10057.1 | 597.0 | 0.942 | 1.44(1.42,1.45) | ||
0.05 | None | 1021.3 | 21.2 | 0.944 | 1.42(1.41,1.43) | |
20% g | 2228.5 | 493.1 | 0.948 | 1.42(1.41,1.43) | ||
20% g & 20% f | 10074.4 | 597.8 | 0.948 | 1.42(1.42,1.43) | ||
0.142 | None | 1027.9 | 27.7 | 0.949 | 1.42(1.41,1.42) | |
20% g | 2240.0 | 497.4 | 0.945 | 1.42(1.41,1.42) | ||
20% g & 20% f | 10198.4 | 601.0 | 0.945 | 1.42(1.41,1.42) | ||
0.25 | None | 1032.0 | 31.7 | 0.952 | 1.41(1.41,1.42) | |
20% g | 2236.9 | 497.8 | 0.954 | 1.42(1.41,1.42) | ||
20% g & 20% f | 10333.8 | 601.2 | 0.953 | 1.42(1.41,1.42) | ||
0.4 | None | 1031.0 | 30.6 | 0.954 | 1.41(1.41,1.42) | |
20% g | 2193.7 | 489.2 | 0.957 | 1.41(1.41,1.42) | ||
20% g & 20% f | 10357.3 | 593.2 | 0.958 | 1.41(1.41,1.42) |
Abbreviations: TT, transmission tetratype; CI, confidence interval
None: no missing data; 20% g: 20% of SNP genotypes are missing randomly; 20%g & 20% f: 20% of SNP genotypes are missing randomly and 20% of triads have missing father.
The 95% CI is based on the empirical standard error calculated using the estimates from 5000 independent simulations.