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Interactions of caspase-3, 6 and 7 with Ac-LDESD-CHO. (a) Caspase-3/LDESD. (b) Caspase-6/LDESD. (c) Caspase-7/LDESD. Thicker lines represent the peptide analog inhibitor. The inhibitor is covalently bonded to the catalytic cysteine. Dashed lines represent hydrogen bonds and ion pairs, while curved lines indicate van der Waals interactions. Similar interactions were observed in the two binding sites in the heterotetramers.
