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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Cancer Res. 2009 Jun 23;69(13):5364–5373. doi: 10.1158/0008-5472.CAN-08-4135

Figure 4.

Figure 4

Wnt signaling represses differentiation. Western blot and qRT-PCR analysis for Slug (A), Twist (B), and SOX17 (C) in SUM1315 cells transfected with DKK1. D, differential gene expression of differentiation genes from wnt-inhibited cell lines. Heatmap Builder Software was used to analyze the data. Starred (*) genes represent those of myoepithelial differentiation, whereas unstarred genes represent luminal differentiation. Western blot analysis of α-smooth muscle actin expression in Control-SUM1315, SFRP1-SUM1315, and DKK1-SUM1315 cells to confirm the qRT-PCR results from left.