Figure 4. UV irradiation leads to IGF-1R and GHR attenuation in quiescent and terminally differentiated cells.
A) Quiescent C5RO primary human fibroblasts were treated 6 days after transfer to 1% FCS medium and samples taken 6hrs post UV treatment. IGF-1R and GHR expression levels were normalized to Gapdh and gTUB. B) Primary rat neurons were treated with UV and IGF-1R and GHR expression was normalized to Hprt and Gapdh (FC = fold change compared to untreated controls; *=p<0.05, **=p<0.01, two-tailed t-test, error bars = SD; n=4; scale bar 25µm).