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. Author manuscript; available in PMC: 2009 Nov 25.
Published in final edited form as: Nat Cell Biol. 2009 Apr 12;11(5):604–615. doi: 10.1038/ncb1866

Figure 6. Attenuation of IGF1-R and GHR expression in response to illudin S but not to oxidative damage and ionizing irradiation.

Figure 6

Primary MDFs were treated with hydrogen peroxide (A) or ionizing radiation (B) and IGF-1R and GHR expression levels were evaluated after 6 h by qPCR and normalized to gTUB and B2M. p21 expression was included as control for DNA damage response. Illudin S treatment leads to IGF-1R and GHR attenuation in quiescent human fibroblasts (C) and rat neurons (D), normalized to Gapdh and gTUB (C) or Hprt and Gapdh (D) (FC = fold change compared to untreated controls; **=p<0.01, two-tailed t-test, error bars = SD; n=4).