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Differential morphology in APOE3/3 and APOE4/4 primary microglial cultures. Typical resting (non-immune stimulated) APOE3/3 (left panel) or APOE4/4 (right panel) microglial cultures were viewed under brightfield microscopy. Microglia from APOE4/4 mice were consistently observed to be less branched and demonstrated a rounded, more ameboid appearance compared to APOE3/3 microglia.
