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The effect of APOE4 is dependent on the allelic dose. Average supernatant levels of nitrite (± SEM) were measured for APOE3/3, APOE2/4, APOE3/4 or APOE4/4 microglial cultures stimulated for 24 hrs with recombinant murine IFNγ (100 U/ml) alone or plus LPS (100 ng/ml). A significant (p < 0.001, 1-way ANOVA) increase in nitrite levels was found for increasing APOE4 gene numbers under both stimulation conditions
