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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Sep 1;19(21):6233–6236. doi: 10.1016/j.bmcl.2009.08.090

Figure 1.

Figure 1

(a) Down-regulation of ErbB2(Her2) expression can be accomplished by blocking the activator-coactivator interactions responsible for initiating gene expression with transcriptional activation domain (TAD) mimics.4, 10, 11 (b) Amphipathic isoxazolidines that mimic the function and mechanism of transcriptional activation domains when attached to a DNA binding domain (‘DBD’).6-9