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. Author manuscript; available in PMC: 2009 Nov 25.
Published in final edited form as: Nature. 2008 Jan 10;451(7175):147–152. doi: 10.1038/nature06487

Figure 3. Clinical association of miR-335 and miR-126 with metastasis-free survival.

Figure 3

a, miR-335, miR-126, miR-122a and miR-199a expression was assessed in a set of 20 primary breast tumour samples through qRT-PCR. Kaplan-Meier curves depict metastasis-free survival of patients whose primary tumours contained low or high levels of the indicated miRNAs. P-values were obtained using a log-rank test. b, The parental MDA-MB-231 cells were transfected with antagomirs targeting endogenous miR-335, miR-199a* or a control antagomir. Four days after transfection, 1 × 104 LM2 cells from each cohort were inoculated intravenously into immunodeficient mice. Lung colonization was measured by bioluminescence at day 35 and quantified. n = 5; error bars represent s.e.m.; P-values based on a one-sided rank-sum test.