TABLE 5.
Association of Changes in z Scores for Metabolic Parameters From Baseline to Week 48 With Measures of Disease Status and ART
| Metabolite (n) | CD4% Change From Baseline to Week 48 (Per 10% Increase) |
HIV RNA <400 Copies per mL at Week 48 (vs ≥400 Copies per mL) |
Antiretroviral Therapy on Study (vs NNRTI Based) |
|||||
|---|---|---|---|---|---|---|---|---|
| NNRTI and PI Based | PI Based | |||||||
| Difference in Adjusted z | P | Difference in Adjusted z | P | Difference in Adjusted z | P | Difference in Adjusted z | P | |
| Score Change (95% CI) | Score Change (95% CI) | Score Change (95% CI) | Score Change (95% CI) | |||||
| From Entry to Week 48 | From Entry to Week 48 | From Entry to Week 48 | From Entry to Week 48 | |||||
| HDL cholesterol (n=53) | 0.67 (0.02 to 1.33) | .044a | −0.17 (−1.10 to 0.76) | .710 | −0.15 (−1.49 to 1.19) | .820 | −0.07 (−1.27 to 1.13) | .910 |
| LDL cholesterol (n=53) | 0.04 (−0.84 to 0.91) | .930 | 0.98 (−0.28 to 2.23) | .120 | 0.09 (−1.76 to 1.94) | .920 | −0.34 (−2.00 to 1.32) | .680 |
| Total cholesterol (n=54) | 0.14 (−0.47 to 0.75) | .650 | 0.90 (0.01 to 1.78) | .047a | 1.06 (−0.20 to 2.33) | .097 | −0.03 (−1.18 to 1.13) | .960 |
| Total-HDL cholesterol ratio (n=53) |
−0.71 (−1.32 to−0.11) | .023a | 0.73 (−0.13 to 1.60) | .094 | 1.32 (0.09 to 2.55) | .036a | −0.07 (−1.17 to 1.02) | .890 |
| Triglycerides (n=54) | 0.02 (−0.55 to 0.60) | .930 | 0.31 (−0.56 to 1.19) | .480 | 1.44 (0.23 to 2.64) | .021a | 0.60 (−0.51 to 1.70) | .280 |
| Apolipoprotein A1 (n=37) | 0.76 (0.00 to 1.52) | .051 | −0.11 (−1.20 to 0.97) | .830 | −1.65 (−3.47 to 0.18) | .074 | −1.78 (−3.62 to 0.05) | .056 |
| Apolipoprotein B (n=37) | −0.59 (−1.42 to 0.25) | .160 | 0.79 (−0.40 to 1.99) | .180 | 0.56 (−1.40 to 2.51) | .560 | −0.81 (−2.77 to 1.15) | .400 |
n is the number of observations included in the analyses; Results are from multivariate models that were adjusted for z score, CD4%, log10 HIV-1 RNA, and CDC category at baseline and dietary intake in excess of recommended cholesterol and total fat; z scores calculated by using age-, gender-, and race/ethnicity-matched control subjects from NHANES (see “Methods”). There were no significant associations with changes in glucose, insulin, or HOMA-IR at 24 or 48 weeks.
a
Significant (P<.05).