TABLE 6.

Associations of IGF-1 With Lipids in P1010 Study Population

Metabolite	Mean Metabolite z Score (SD) at Entry (n)			Mean Metabolite z Score (SD) Change at 48 Weeks (n)
	Low IGF-1	Normal IGF-1	P	IGF-1 Category Stable or Decreased	IGF-1 Category Increased From Low to Normal	P
HDL cholesterol	−2.08 (1.03) (21)	−0.56 (1.11) (44)	<.001a	0.30 (1.50) (42)	1.96 (1.17) (8)	.005a
LDL cholesterol	−0.81 (2.26) (21)	−0.06 (1.29) (44)	.230	0.31 (1.79) (42)	1.01 (2.31) (8)	.340
Total cholesterol	−1.18 (1.66) (21)	−0.317 (1.225) (44)	.024a	0.66 (1.32) (43)	1.08 (1.58) (8)	.420
Total-HDL cholesterol ratio	1.18 (1.44) (21)	0.33 (1.20) (44)	.046a	0.16 (1.27) (42)	−1.09 (1.36) (8)	.014a
Triglycerides	0.58 (1.38) (21)	0.31 (1.41) (44)	.270	0.24 (1.46) (43)	−0.10 (1.16) (8)	.550
Apolipoprotein A1	−1.44 (0.88) (17)	0.04 (1.28) (37)	<.001a	0.56 (1.24) (33)	2.03 (1.67) (5)	.023a
Apolipoprotein B	0.031 (1.58) (17)	0.06 (1.50) (37)	.820	0.57 (1.19) (33)	0.62 (1.70) (5)	.940

n is the number of observations included in the analyses. P values are for Student’s t test difference between group means.

^aSignificant (P<.05).