(A) hTCEpi cells grown on glass-bottom tissue culture dishes triple-labeled with Calcein-AM (live cells, green), Annexin V (early apoptotic cells, blue), and PI (dead cells, red) following incubation in rhIGFBP3. Membrane blebbing was seen in occasional cells at 24 hours. 20× magnification, scale: 44 μm. (B) hTCEpi cells grown on glass-bottom tissue culture dishes triple-labeled with Calcein-AM (live cells, green), Annexin V (early apoptotic cells, blue), and PI (dead cells, red) following incubation in TSA. Significant apoptosis was visible at 24 hours. 20× magnification, scale: 75 μm.