Table 1.

Effects of DOCA/HS on urine volume, urinary Na and K excretion in wild type and COMT −/− mice

	Wild type		COMT −/−
Group	control	DOCA/HS	control	DOCA/HS	DOCA/HS/C2I
24-H urine volume, ml	1.1 ± 0.1	6.4 ± 1.6*	1.2 ± 0.2	21.6 ± 3.3*†	4.2 ± 1.1*‡
24-H urinary Na excretion, μM	123 ± 10	659 ± 102*	131 ± 20	3038 ± 430*†	399 ± 82*‡
24-H urinary K excretion, μM	164 ± 20	134 ± 19	253 ± 36	228 ± 42	128±16

Values are means ± S.E.M. Animals were caged individually for 24 h and urine sample was collected.

^*P < 0.01 vs. control;

^†P < 0.01 vs. DOCA/HS wild type;

^‡P < 0.01 vs. DOCA/HS COMT−/−; n = 6 in each group. HS: 1% NaCl in drinking water; C2I: COX-2 inhibitor SC58236.