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Initial screening of ADAMTS-4 inhibitors using the substrate fTSSlong.
| Inhibitor Structure | Inhibitor Name | Compound Number | FRET Assay IC50 (μM) | RP-HPLC Assay IC50(μM) |
|---|---|---|---|---|
 |
resveratrol | 4 | 50 | >100 |
 |
trans-stillbene | 5 | >100 | >100 |
 |
cis-stillbene | 6 | ~100 | >100 |
 |
deoxyrhapontin | 7 | 20 | >100 |
 |
rhapontin | 8 | 50 | >100 |
 |
pyrocatechol | 9 | 20 | >100 |
 |
pyrogallol | 10 | 5 | 5 |
Assays were performed in duplicate.
