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Inhibition of ADAMTS-4 and ADAMTS-5 by compounds 3 and 10.
| Enzyme | Substrate | Inhibitor Structure | Inhibitor | Ki (μM) |
|---|---|---|---|---|
| ADAMTS-4 | fTSSshort |  |
3 | 5.06 ± 0.54 |
| fTSSlong | 2.68 ± 0.28 | |||
| ADAMTS-5 | fTSSshort | 11.08 ± 3.95 | ||
| fTSSlong | 1.18 ± 0.17 | |||
| ADAMTS-4 | fTSSshort |  |
10 | 41.12 ± 9.77 |
| fTSSlong | 6.34 ± 0.53 | |||
| ADAMTS-5 | fTSSshort | 36.90 ± 8.82 | ||
| fTSSlong | 3.63 ± 0.61 |
