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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Dev Dyn. 2009 Sep;238(9):2149–2162. doi: 10.1002/dvdy.22033

Figure 3. Retinoic acid signaling during development of the anterior segment.

Figure 3

(A) Simplified overview of retinoic acid production and function in intracrine or paracrine signaling. Note: addition factors involved in functions such as transport have been omitted for simplicity. (B) Summary of tissues producing retinoic acid (blue) at e11.5 based on expression of RALDH1 and/or RALDH3. (C) Summary of tissues responding to retinoic acid signaling at e11.5 based on expression pattern of RARE-lacZ reporter transgene. Key: C, cornea; ADH, alcohol dehydrogenase; RAR, retinoic acid receptor; RALDH1-3, retinaldehyde dehydrogenase 1-3; RDH10, retinol dehydrogenase 10; M, mesenchyme; OS, optic stalk; R, retina; PRE, retinal pigmented epithelium; RXR, retinoid X receptor.