Table 1. Comparisons of anti-cancer therapeutics used in this study.
Common Name | Camptothecin | Docetaxel | Rapamycin |
Trademarked Name | Topotecan, Irinotecan | Taxotere | Sirolimus, Everolimus |
Molecular Weight | 348.4 g/mol | 807.9 g/mol | 914.2 g/mol |
Solubility in water | 10.9 μM | 7.4-8.7 μM | 2.8 μM |
Mechanism of Action | Stabilizes Topoisomerase I preventing DNA re-ligation | Inhibits microtubule depolymerization | Inhibits mTOR pathway |
Cell Processes Impacted | DNA Replication | Cell Division, Cellular Trafficking | Transcription |