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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Biomaterials. 2009 Aug 19;30(30):6076–6085. doi: 10.1016/j.biomaterials.2009.07.054

Table 1. Comparisons of anti-cancer therapeutics used in this study.

Common Name Camptothecin Docetaxel Rapamycin
Trademarked Name Topotecan, Irinotecan Taxotere Sirolimus, Everolimus
Molecular Weight 348.4 g/mol 807.9 g/mol 914.2 g/mol
Solubility in water 10.9 μM 7.4-8.7 μM 2.8 μM
Mechanism of Action Stabilizes Topoisomerase I preventing DNA re-ligation Inhibits microtubule depolymerization Inhibits mTOR pathway
Cell Processes Impacted DNA Replication Cell Division, Cellular Trafficking Transcription