Table 1. Demographic feature of affected individuals.
| Average | ||||||||
|---|---|---|---|---|---|---|---|---|
| Population | Cases | Controls | Trios | Age (years) | Disease duration (years) | EDSS | RR/SP% | PP% |
| Screening phase | ||||||||
| Belgium | 368 | 374 | 113 | 47.0 | 15.0 | 5.4 | 91.2 | 8.8 |
| Norway | 638 | 1026 | — | 46.3 | 14.3 | 4.8 | 81.4 | 18.6 |
| UK1 | 475 | 479 | 693 | 43.8 | 12.8 | 4.6 | 88.2 | 11.8 |
| WTCCC screen | 979 | 1470 | — | 43.2 | 13.5 | 4.7 | 87.2 | 12.8 |
| Replication phase | ||||||||
| Australia | — | — | 372 | 47.2 | 14.3 | 3.3a | 93.0 | 7.0 |
| UK2 | 1531 | 561 | — | 44.0 | 13.0 | 4.6 | 91.8 | 8.2 |
| USA | 1222 | 543 | 875 | 44.3 | 12.4 | 4.1 | 94.8 | 5.2 |
EDSS, expanded disability status scale; RR, relapse remitting; SP, secondary progressive; PP, primary progressive. The case dataset from UK2 includes 880 from the North West of the UK and 516 from South Wales with the remainder coming from across the whole of the UK (with an emphasis on the South east). The control dataset includes 561 individuals from the 1958 birth cohort.
a
The EDSS was not determined for these patients; instead, the average ‘disease steps' measure is shown.34