. Author manuscript; available in PMC: 2009 Nov 25.

Published in final edited form as: J Med Chem. 2008 Apr 12;51(9):2668–2675. doi: 10.1021/jm701444y

Table 3. Distances between C_γ atoms (in Å) of selected residues for the analogues studied by NMR and the selective sst-pharmacophores.

Analogue	F⁶ - F⁷	F⁶ - ^DW⁸	F⁶ - K⁹	F⁶ - F¹¹	F⁷ - ^DW⁸	F⁷ - K⁹	F⁷ - F¹¹	^DW⁸ - K⁹	^DW⁸ - F¹¹	K⁹ - F¹¹
1	7.2-8.0	10.0-10.2	7.9-9.6	7.6-9.7	4.7-4.9	9.3-10.8	11.8-14.5	7.4-8.9	11.7-13.7	5.9-10.6
3	7.6-7.7	8.4-8.6	11.0-11.7	13.2-13.6	8.0-8.1	5.6-6.5	7.1-8.2	5.7-5.9	8.9-9.4	5.0-5.2
18	8.6-8.6	10.0-10.1	5.4-5.5	8.4-8.9	5.5-5.5	9.4-9.4	8.7-9.9	7.5-7.5	12.0-13.0	11.5-11.6
19	5.1-7.5	7.8-8.6	5.3-7.1	6.6-10.2	7.3-8.2	9.1-10.3	12.6-13.4	5.9-6.2	8.9-10.7	4.4-6.0
21	4.8-5.1	8.7-8.9	7.3-8.0	12.6-13.8	6.4-6.4	5.5-5.7	11.9-13.7	7.0-7.1	6.6-9.5	10.1-10.5
sst₁ pharmacophore	-	-	-	-	6.0-7.5	9.0-11.0	6.0-7.5	7.0-8.0	9.5-12.0	8.0-10.0
sst₄ pharmacophore	-	5.5-9.5	4.5-6.5	-	-	-	-	4.5-6.5	5.5-9.5	4.5-6.5
	F² - F⁷	F² - ^DW⁸	F² - K⁹
sst₂ pharmacophore	-	12.0-13.5	12.5-15.0	-	-	-	-	4.0-5.0	-	-
octreotide pharmacophore	5.0-11.0	11.0-15.0	12.0-15.0	-	7.0-9.0	9.0-11.0	-	5.0-5.0	-	-

Table 3. Distances between Cγ atoms (in Å) of selected residues for the analogues studied by NMR and the selective sst-pharmacophores.