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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Prostate. 2009 Nov 1;69(15):1694–1703. doi: 10.1002/pros.21020

Figure 1.

Figure 1

TCR Vβ skewing of select Vβ families in peripheral blood and prostate of PCa patients. A) Examples of skewing observed by TCR Vβ CDR3 spectratyping. Skewed CDR3 sizes in CD8+ PIL are observed in both the right and left lobes of the prostate, but not in the peripheral blood. B-E) Positively isolated CD8+ T cells were stained directly ex vivo and analyzed by flow cytometry. Representative FACS plots of CD3+CD8+Vβ2+, CD3+CD8+Vβ8+, CD3+CD8+Vβ13.6+, and CD3+CD8+Vβ14+ T cells in peripheral blood and prostate tissue of PCa patients are shown as well as a summary of the data. Several individual patients demonstrate a relative up-regulation of a particular Vβ family within the prostate gland. P values were calculated by paired Student’s t test, two sided.