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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Prostate. 2009 Nov 1;69(15):1694–1703. doi: 10.1002/pros.21020

Figure 4.

Figure 4

Prostate-infiltrating CD8+ T cells exhibit an exhausted phenotype. A) FACS analysis of prostate-infiltrating CD8+ T cells. Plots are gated on CD8+ T cells and gates set using appropriate isotype controls. Far right, mean fluorescence intensity (MFI) comparison of peripheral blood CD8+PD-1+ T cells (black histogram) and prostate CD8+PD-1+ T cells (gray histogram). B) Summary of data above. % CD8+ T cells positive for PD-1 are shown. Bar = mean. C) Summary of data above. PD-1 MFI is shown. Bar = mean. P values were calculated for control peripheral blood (P. blood) versus PCa P. blood by unpaired Student’s t test, two sided and for PCa P. blood versus prostate by paired Student’s t test, two sided. D) Correlative analysis for PD-1 MFI for PCa P. blood versus prostate for low grade (Gleason 6) versus high grade (Gleason 7-9) disease.