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. Author manuscript; available in PMC: 2009 Nov 25.
Published in final edited form as: Bioorg Med Chem Lett. 2007 Nov 28;18(2):571–575. doi: 10.1016/j.bmcl.2007.11.077

Scheme 3.

Scheme 3

Dimerization of P2X7 receptor antagonists through formation of a thiourea linkage. Reagents and conditions: (a) NaBH4, Cu(acac)2, methanol, rt, 80–85%; (b) CSCl2, chloroform, water, sodium bicarbonate, 70–85%; (c) 1,4-diaminobutane, CH2Cl2, rt, 40–45%; (d) dry DMF, at 80 °C, 52%.