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The Ras Hypervariable Region (HVR). (A) Ras isoform C-terminal HVRs have different combinations of post-translational lipid modifications and membrane interacting polybasic motifs that specify differential trafficking and localization. (B) Ras isoform localization is dynamic; changes in H- and N-Ras activation state or palmitoylation alter the association with cell surface subdomains/clusters and endomembranous compartments.
