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. Author manuscript; available in PMC: 2010 Sep 25.
Published in final edited form as: Mol Cell. 2009 Sep 24;35(6):856–867. doi: 10.1016/j.molcel.2009.09.006

Figure 7.

Figure 7

HOXA1 is regulated by mir-210 in vivo. A) HOXA1 protein in harvested tumor xenograft samples. Top panel, mir-210 expression in each sample; bottom panel, HOXA1 protein level in corresponding samples. The left and right arrows in the top panel indicate the input parental and input mir-210 expressing cells, respectively. Dotted line indicates two groups of samples with inversed profiles of mir-210 expression and HOXA1 protein level. B) The inhibitory effect of mir-210 on tumor growth initiation was partially rescued by expressing HOXA1 or FGFRL1 coding sequence without a 3′ UTR region. Each group of FaDu cells was injected s.c in nude mice at a density of 2.5x106 cells. N=7 for the each group. C) Expressing PIM1 coding sequence without a 3′ UTR region has no effect on the inhibitory effect of mir-210 on tumor growth initiation. Each group of FaDu cells was injected s.c in nude mice at a density of 3x106 cells. N=7 for the each group.