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. Author manuscript; available in PMC: 2009 Nov 25.
Published in final edited form as: Methods Enzymol. 2009;457:349–372. doi: 10.1016/S0076-6879(09)05020-4

Figure 1. Overview of mitochondrial oxidative phosphorylation. P.

Figure 1

hosphorylation of ADP to ATP at complex V (ATP synthase) is driven by a proton gradient across the inner mitochondrial membrane. Oxidation of carbon substrates in the tricarboxylic acid (TCA) cycle generates reducing equivalents that subsequently provide electron flow to the electron transport system. Electrons are transferred from NADH through complex I (NADH dehydrogenase) and oxidation of succinate by complex II (succinate dehydrogenase). Electron flow from other sources such as electron transferring flavoprotein is not shown.