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Schematic representation of PELP1/MNAR signaling in cancer cells. PELP1 role in ER genomic and nongenomic functions is depicted by placing PELP1/MNAR in both cytoplasmic and nuclear compartments along with the identified complexes. Deregulation of PELP1/MNAR in cancer cells might contribute to the hypersensitivity of tumor cells by enhancing genomic as well as nongenomic ER actions and thus promote tumorigenesis and hormonal therapy resistance.
