Table 1.

Index of estrogen doses and concentrations produced endogenously or administered exogenously, across the lifespan and for depression treatment

	Dose	Estradiol concentration (pmol/L)	Reference
PHYSIOLOGIC CONCENTRATIONS
Prepubertal		40	Adashi text 1996
Menstrual cycle range	Ovarian follicle secretes 70 – 500 mcg/d, phase-dependent	180 - 1100	Adashi text 1996
Mean menstrual cycle		370	Adashi text 1996
End first trimester gestation		9,200	Adashi text 1996
End second trimester gestation		37,000	Adashi text 1996
End third trimester gestation		60,000	Adashi text 1996
Lactational amenorrhea		70	Peerhentupa 2004
		150	Peerhentupa 2000
		152 (n=49) breastfeeding	Lawrie 1998
Postpartum – 6 weeks - bottlefeeding		340 (n=9) bottle feeding	Lawrie 1998
Hypogonadal/postmenopausal		< 110	Adashi text 1996
REPRODUCTIVE ENDOCRINE TREATMENTS
Postmenopausal hormone therapy	Estradiol 25 – 200 mcg/d	250 – 600	Physicians' Desk Reference
DEPRESSION TREATMENT
Postmenopausal depression treatment	50 mcg/d (changed q3days)	550	Schmidt 2000
	100 mcg/d (changed 2x/wk)	260	Soares 2001
Postpartum depression treatment	200 mcg/d (changed 2x/wk)	680	Gregoire 1996
	3-8 mg/d sublingual	Mean=500 (range 320-710)	Ahokas 2001
HPO AXIS RESEARCH
Lactation, 20-22 wks postpartum	Estroderm 50(changed 2x/wk)	100	Perheentupa 2004 (data estimated from graphic)
	75	80
	100 mcg/d	170
Lactation, 6-1 wks postpartum	Estroderm 50(changed 2x/wk)	Ranged from 100-200 over 12 wks	Perheentupa 2000 (data estimated from graphic)