Figure 1.

High-resolution proton MRI used for anatomical reference. The coronal image (a) shows the location of the slices acquired in the ¹³C-CSI data sets with a temporal resolution of 6 s. The yellow squares (interpolated nominal size in-plane: 1.25×1.25 mm²) in the axial images from slices through the liver (b) and kidney (c) indicate the origin of the spectra shown in Fig. 2. Also shown in green are the ROIs evaluated for measuring the time courses of the individual metabolites (Fig. 4). The axial images have been cropped to the size of the metabolic images. The middle slice (c) shows the Lac phantom on top of the animal, below the animal is the water-filled blanket (for heating of the animal).