Table 3.
| Table 3a Mean baseline lipid concentrations according to ER-α XbaI genotype and menopausal status | |||||
|---|---|---|---|---|---|
| ER-α XbaI genotype | Lipid particle | AA (n=50) | AG (n=59) | GG (n=19) | P-valuea |
| All women (N=128)b | Total cholesterol | 223 (215, 231)c | 214 (206, 222) | 244 (228, 260) | 0.017 |
| Triglycerides | 131 (109, 153) | 132 (110, 154) | 142 (102, 182) | 0.63 | |
| HDL-cholesterol | 61 (57, 65) | 63 (59, 67) | 65 (57, 73) | 0.49 | |
| LDL-cholesterol | 135 (128, 142) | 125 (117, 133) | 150 (136, 164) | 0.03 | |
| Premenopausal women (N=53) | Total cholesterol | 206 (184, 229) | 206 (192, 220) | 244 (212, 276) | 0.04 |
| Triglycerides | 119 (67, 171) | 113 (83, 157) | 142 (66, 218) | 0.53 | |
| HDL-cholesterol | 61 (54, 70) | 66 (59, 71) | 67 (55, 79) | 0.61 | |
| LDL-cholesterol | 120 (101, 137) | 118 (105, 129) | 148 (122, 174) | 0.04 | |
| Postmenopausal women (N=81) | Total cholesterol | 230 (218, 242) | 222 (208, 236) | 243 (221, 265) | 0.16 |
| Triglycerides | 135 (112, 160) | 152 (124, 180) | 142 (100, 184) | 0.94 | |
| HDL-cholesterol | 61 (57, 65) | 60 (54, 66) | 64 (54, 74) | 0.54 | |
| LDL-cholesterol | 141 (131, 151) | 131 (119, 143) | 151 (131, 171) | 0.20 | |
| Table 3b Association of total cholesterol concentration change at 4 months with ER-α XbaI genotypes (postmenopausal group) | ||||
|---|---|---|---|---|
| ER-α XbaI genotype |
||||
| Lipid particle | AA (n=36) | AG (n=29) | GG (n=12) | P-valuea |
| Total cholesterol | −22 (−30, −14)b | −20 (−30, −10) | −40 (−58, −22) | 0.03 |
| Triglycerides | 17 (−19, 53) | 33 (−9, 74) | 29 (−35, 93) | 0.07 |
| HDL-cholesterol | 0 (−3.4, −3.4) | 1.3 (−2.7, 5.3) | −1.2 (−7.2, 4.8) | 0.19 |
| LDL-cholesterol | −25 (−33, −17) | −23 (−33, −13) | −40 (−56, −24) | 0.08 |
CI, confidence interval; ER-α, estrogen receptor alpha; HDL, high-density lipoprotein; LDL, low-density lipoprotein.
a
P-values are calculated for the differences between the AA/AG and the GG alleles.
b
Number of ER-α genotypes available.
c
Mean baseline lipid particle concentration (95% CI).
CI, confidence interval; ER-α, estrogen receptor alpha; HDL, high-density lipoprotein; LDL, low-density lipoprotein.
a
P-values are calculated for the differences between baseline and 4 months concentration for the AA/AG vs the GG alleles.
b
Change in serum lipid particle concentration is shown in mg/dl with 95% CI.