. Author manuscript; available in PMC: 2009 Nov 25.

Published in final edited form as: J Toxicol Environ Health B Crit Rev. 2007;10(Suppl 1):1–269. doi: 10.1080/10937400701597766

Table 25.

Strength of evidence for health effects.

			Exposure Pathway^a
Health Endpoint^b		Inhalation	Oral	Dermal	Injection
1	Acute toxicity
2	Irritation	Strong	Limited	Limited	Strong
3	Corrosivity
4	Sensitization
5	Repeated dose toxicity
6	Mutagenicity	Limited	Limited
7	Carcinogenicity	No clear evidence	No clear evidence
8	Reproductive toxicity	Limited	Modest		No clear evidence
9a	Other – Neurological Toxicity	Limited	Modest		Modest
9b	Other – Bone Toxicity		No clear evidence		Modest
9c	Other – Metabolism		Limited		Limited

The absence of an entry indicates that, effectively, there are no data for the exposure pathway / toxicity endpoint combination.

Health endpoint categories are taken from European Commission (2003).