Table 1.
Parameter | FVB (34) | MT (34) | FVB-DAHP (32) | MT-DAHP (31) |
---|---|---|---|---|
Body Weight (g) | 26.44 ± 0.42 | 27.48 ± 0.67 | 26.68 ± 0.45 | 27.56 ± 0.65 |
Heart Weight (HW, mg) | 153 ± 7 | 156 ± 8 | 156 ± 8 | 148 ± 7 |
HW/Body Weight (mg/g) | 5.77 ± 0.23 | 5.61 ± 0.20 | 5.89 ± 0.30 | 5.41 ± 0.21 |
Liver Weight (LW, g) | 1.42 ± 0.05 | 1.40 ± 0.07 | 1.41 ± 0.05 | 1.38 ± 0.05 |
LW/Body Weight (mg/g) | 53.7 ± 1.7 | 50.4 ± 1.6 | 53.1 ± 1.4 | 50.3 ± 1.4 |
Kidney Weight (KW, g) | 0.341 ± 0.011 | 0.346 ± 0.014 | 0.360 ± 0.013 | 0.369 ± 0.014 |
KW/Body Weight (mg/g) | 12.89 ± 0.30 | 12.45 ± 0.27 | 13.60 ± 0.41 | 13.34 ± 0.31 |
Systolic BP (mmHg) | 103.3 ± 3.1 | 105.5 ± 3.2 | 145.8 ± 10.7* | 140.5 ± 6.3* |
Diastolic BP (mmHg) | 72.5 ± 10.0 | 75.5 ± 5.5 | 117.0 ± 12.7* | 101.8 ± 8.6* |
Blood Glucose (mM) | 5.10 ± 0.26 | 5.34 ± 0.27 | 5.41 ± 0.25 | 5.22 ± 0.30 |
Heart Rate (bpm) | 545 ± 15 | 541 ± 20 | 557 ± 24 | 544 ± 19 |
Wall Thickness (mm) | 0.871 ± 0.049 | 0.927 ± 0.063 | 0.712 ± 0.043* | 0.868 ± 0.019† |
EDD (mm) | 2.32 ± 0.16 | 2.29 ± 0.21 | 2.04 ± 0.14 | 2.24 ± 0.16 |
ESD (mm) | 1.15 ± 0.11 | 1.11 ± 0.12 | 1.42 ± 0.09* | 1.23 ± 0.10† |
LV Mass (mg) | 66.9 ± 6.2 | 62.4 ± 9.2 | 53.6 ± 9.6 | 66.9 ± 8.5 |
Normalized LV Mass (mg/g) | 2.35 ± 0.20 | 2.27 ± 0.30 | 1.92 ± 0.34 | 2.42 ± 0.28 |
Fractional Shortening (%) | 50.6 ± 2.6 | 50.9 ± 4.1 | 36.7 ± 1.9* | 45.3 ± 2.8† |
Mean ± SEM,
p < 0.05 vs. FVB group,
p < 0.05 vs. FVB-DAHP group,
number of mice per group is given in parentheses.