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. Author manuscript; available in PMC: 2009 Nov 25.

Published in final edited form as: N Engl J Med. 2006 Jun 1;354(22):2340–2348. doi: 10.1056/NEJMoa054391

GERD symptoms were defined as heartburn (“a burning pain or discomfort behind the breast bone in your chest”) and/or acid regurgitation (“a bitter or sour-tasting fluid coming into your throat or mouth”). Frequent GERD symptoms were those occurring at least weekly. Multivariate ORs are based upon 2,306 cases and 3,904 controls and have been adjusted for age; smoking status; total activity; daily caloric intake; alcohol intake; coffee, tea, and chocolate consumption; post-menopausal hormone therapy; anti-hypertension medication use; asthma medication use; and diabetes mellitus.

*Odds Ratio (OR: 95% CI) of body mass index (BMI) by 7 categories for women who had GERD symptoms within last year. Multivariate model was adjusted for age, total activity (METS/Wk), anti-hypertension medication use, asthma medication use in past 12 months, history of diabetes, depression, stress from care, total coffee and tea consumption, total caffeine, alcohol intake, regular soft drink, diet soft drink, juice, fruit punch, smoke status, HRT, aspirin use, other NSAID use, acetaminophen use, trans fat, saturated fat, polyunsaturated fat, monounsaturated fat, omega 3 acid, total protein, total carbohydrate, total calorie intake, chocolate, fruit and vegetable, antilog AOAC fiber and salt.

*Odds Ratio (OR: 95% CI) of body mass index (BMI) by 7 categories for women who had at least weekly GERD symptoms. Multivariate model was adjusted for age, total activity (METS/Wk), anti-hypertension medication use, asthma medication use in past 12 months, history of diabetes, depression, stress from care, total coffee and tea consumption, total caffeine, alcohol intake, regular soft drink, diet soft drink, juice, fruit punch, smoke status, HRT, aspirin use, other NSAID use, acetaminophen use, trans fat, saturated fat, polyunsaturated fat, monounsaturated fat, omega 3 acid, total protein, total carbohydrate, total calorie intake, chocolate, fruit and vegetable, antilog AOAC fiber and salt.

GERD symptoms were defined as heartburn (“a burning pain or discomfort behind the breast bone in your chest”) and/or acid regurgitation (“a bitter or sour-tasting fluid coming into your throat or mouth”). Frequent GERD symptoms were those occurring at least weekly. Multivariate ORs are based upon 2,306 cases and 3,904 controls and have been adjusted for age; smoking status; total activity; daily caloric intake; alcohol intake; coffee, tea, and chocolate consumption; post-menopausal hormone therapy; anti-hypertension medication use; asthma medication use; and diabetes mellitus.

*Odds Ratio (OR: 95% CI) of body mass index (BMI) by 7 categories for women who had GERD symptoms within last year. Multivariate model was adjusted for age, total activity (METS/Wk), anti-hypertension medication use, asthma medication use in past 12 months, history of diabetes, depression, stress from care, total coffee and tea consumption, total caffeine, alcohol intake, regular soft drink, diet soft drink, juice, fruit punch, smoke status, HRT, aspirin use, other NSAID use, acetaminophen use, trans fat, saturated fat, polyunsaturated fat, monounsaturated fat, omega 3 acid, total protein, total carbohydrate, total calorie intake, chocolate, fruit and vegetable, antilog AOAC fiber and salt.

*Odds Ratio (OR: 95% CI) of body mass index (BMI) by 7 categories for women who had at least weekly GERD symptoms. Multivariate model was adjusted for age, total activity (METS/Wk), anti-hypertension medication use, asthma medication use in past 12 months, history of diabetes, depression, stress from care, total coffee and tea consumption, total caffeine, alcohol intake, regular soft drink, diet soft drink, juice, fruit punch, smoke status, HRT, aspirin use, other NSAID use, acetaminophen use, trans fat, saturated fat, polyunsaturated fat, monounsaturated fat, omega 3 acid, total protein, total carbohydrate, total calorie intake, chocolate, fruit and vegetable, antilog AOAC fiber and salt.