Table I.
Clinical conditions | Notes | GoR |
---|---|---|
Congenital antithrombin deficiency | ||
Prophylaxis of deep vein thrombosis and thrombo-embolism in high-risk situations | For the entire time that the high-risk state is present | 2C |
Treatment of ongoing thrombosis | Until the indicated level of oral anticoagulation is reached | 2C |
This latter must be maintained life-long in cases of repeated thromboembolism | 2C+ | |
Acquired antithrombin deficiency | ||
Increased consumption (in DIC associated with severe sepsis) | Administration of high doses, not associated with heparin, may improve survival | 2C+ |
|
There is little evidence of the efficacy of treatment with AT in these clinical circumstances |
GoR: Grade of Recommendation