Table II.

Indications for the use of PCC

Congenital deficiencies of clotting factors in the prothrombin complex	GoR
Deficiencies of factors II and X: for prophylaxis or treatment of bleeding. If PCC are not available, FFP can be used as an alternative.	2C
Haemophilia B and inherited factor VII deficiency: when the specific factor IX and VII concentrates are not available.
Haemophilia A with inhibitors, during bleeding episodes (activated PCC).
Acquired deficiencies of clotting factors in the prothrombin complex (Factors II, IX, X)	GoR
Bleeding episodes in the presence of deficiencies of one or more factors of the prothrombin complex.
Limitations to the use of FFP because of the risk of circulatory overload or the need for immediate haemostasis, in the following circumstances:
-severe liver disease with serious bleeding or in preparation for elective surgery carrying the risk of bleeding (liver transplantation);
-vitamin K deficiency in the presence of life-threatening bleeding;
-acquired haemophilia (activated PCC).	2C
-Excessive doses of dicoumarols or the need to suspend them in emergency conditions (acute haemorrhage, urgent surgery).	2C+

GoR: Grade of Recommendation