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. Author manuscript; available in PMC: 2010 Oct 15.

Published in final edited form as: Free Radic Biol Med. 2009 Jul 17;47(8):1147–1153. doi: 10.1016/j.freeradbiomed.2009.07.019

Table 1.

Rat Serum and Liver Metabolites 30 minutes after LA (100 mg/kg) (n = 26) vs. Control IP Injection (n = 15)

	Serum (uM or nM^*)			Liver (nmol/g)
Metabolite	LA	Control		LA	Control
	Mean (SD)	Mean (SD)	p	Mean (SD)	Mean (SD)	p
Lipoic Acid	266 (294)	0.2 (0.4)	0.002	51.9 (52.0)^†	5.8 (11.3)^†	0.001
tHcys	7.3 (1.9)	3.4 (1.1)	<0.001	42.1 (18.0)	31.4 (18.5)	0.120
SAH	507 (757)	33 (12)	0.002	69.6 (13.7)	20.3 (10.5)	<0.001
SAM	177 (86)	205 (71)	0.323	12.8 (8.9)	56.7 (16.0)	<0.001
Cystathionine	935 (186)	773 (261)	0.026	8.5 (3.5)	5.5 (3.5)	0.025
Cysteine	70 (22)	216 (28)	<0.001	1120 (522)	1280 (496)	0.408
Methionine	81.9 (21.7)	63.7 (18.3)	0.009	648 (268)	745 (214)	0.302
N, N-Dimethylglycine	10.8 (3.2)	7.5 (4.1)	0.006	97.2 (32.2)	78.4 (21.1)	0.091
N-Methylglycine	3.4 (0.9)	2.9 (1.4)	0.236	42.1 (14.8)	35.0 (21.8)	0.260
Alpha-aminobutyric acid	6.3 (1.5)	3.9 (0.6)	<0.001	62.5 (40.5)	41.4 (24.6)	0.124

^*

All serum metabolites are shown as umol/L except SAH, SAM and cystathionine, which are nmol/L

^†

N = 19 for LA rats and 8 for control rats for liver lipoic acid