Table 4.

Multivariable logistic regression analysis of characteristics associated with one-year allograft failure after liver re-transplantation ^*

	Combined (n=3977)			Pre-MELD (n=2374)			Post-MELD (n=1603)
Characteristics of interest	O.R.	C.I.	p	O.R.	C.I.	p	O.R.	C.I.	p
Intermediate center volume	0.86	0.72–1.03	0.11	0.74	0.58–0.93	0.01	1.09	0.82–1.46	0.55
High center volume	0.88	0.74–1.04	0.14	0.79	0.63–0.98	0.03	1.05	0.79–1.40	0.72
Recipient characteristics	O.R.	C.I.	p	O.R.	C.I.	p	O.R.	C.I.	p
Age (per ten years)	1.09	1.03–1.17	<0.01	1.11	1.02–1.20	0.02	1.07	0.96–1.18	0.22
Male	0.95	0.83–1.10	0.49	0.94	0.78–1.12	0.48	1.00	0.79–1.27	0.98
Black ethnicity	1.08	0.86–1.36	0.51	0.95	0.68–1.31	0.74	1.19	0.85–1.67	0.31
Diabetes	1.15	0.97–1.36	0.12	0.95	0.75–1.19	0.63	1.48	1.14–1.93	<0.01
Hepatitis C	1.24	1.07–1.44	<0.01	1.14	0.94–1.37	0.19	1.41	1.11–1.78	<0.01
Life support	1.56	1.31–1.87	<0.01	1.57	1.25–1.97	<0.01	1.47	1.08–2.00	0.01
Status 1	1.19	0.97–1.47	0.10	1.30	1.01–1.68	0.04	1.05	0.70–1.57	0.83
MELD score **	NA	NA	NA	NA	NA	NA	1.02	1.01–1.04	<0.01
Dialysis	1.71	1.42–2.07	<0.01	1.69	1.31–2.17	<0.01	1.51	1.09–2.08	0.01
Simultaneous kidney transplant	0.77	0.58–1.02	0.07	0.79	0.53–1.17	0.24	0.76	0.50–1.15	0.19
Quartile of time between transplants ***	Reference			Reference			Reference
2nd quartile	1.35	1.08–1.68	<0.01	1.41	1.07–1.84	0.01	1.25	0.83–1.89	0.28
3rd quartile	1.94	1.48–2.53	<0.01	2.86	2.06–3.96	<0.01	0.99	0.60–1.64	0.97
4th quartile	1.25	0.94–1.66	0.12	1.49	1.04–2.13	0.03	0.90	0.54–1.50	0.69
Donor characteristics	O.R.	C.I.	p	O.R.	C.I.	p	O.R.	C.I.	P
Age (per 10 years)	1.16	1.10–1.22	<0.01	1.17	1.10–1.25	<0.01	1.16	1.07–1.26	<0.01
Male	0.94	0.81–1.09	0.39	0.88	0.73–1.06	0.16	1.08	0.82–1.42	0.58
Black ethnicity	1.41	1.17–1.71	<0.01	1.55	1.21–2.00	<0.01	1.32	0.97–1.78	0.07
Cause of death: CVA	1.06	0.88–1.27	0.54	1.10	0.87–1.38	0.43	0.98	0.74–1.32	0.91
Cause of death: Anoxia	0.92	0.71–1.19	0.52	1.18	0.84–1.66	0.35	0.65	0.43–0.97	0.03
Donation after cardiac death	2.31	1.35–3.95	<0.01	2.51	0.89–7.05	0.08	2.29	1.20–4.38	0.01
Height (per 10 cm)	0.92	0.88–0.95	<0.01	0.93	0.89–0.97	<0.01	0.84	0.74–0.94	<0.01
Allograft characteristics	O.R.	C.I.	p	O.R.	C.I.	p	O.R.	C.I.	P
Allograft shared beyond region	1.25	0.98–1.59	0.08	1.19	0.89–1.59	0.24	1.39	0.87–2.24	0.18
Split liver	1.97	1.23–3.15	<0.01	2.21	1.29–3.77	<0.01	1.58	0.53–4.67	0.41
Quartile of cold ischemia****	Reference			Reference			Reference
2nd quartile	1.11	0.92–1.35	0.28	1.22	0.94–1.58	0.13	1.03	0.76–1.40	0.83
3rd quartile	1.23	1.01–1.50	0.04	1.33	1.02–1.72	0.03	1.15	0.84–1.57	0.39
4th quartile	1.34	1.10–1.63	<0.01	1.42	1.10–1.83	<0.01	1.25	0.90–1.73	0.18
Quartile of warm ischemia *****	Reference			Reference			Reference
2nd quartile	1.03	0.86–1.23	0.78	0.92	0.72–1.17	0.50	1.24	0.94–1.63	0.13
3rd quartile	1.20	0.94–1.54	0.15	1.17	0.85–1.63	0.33	1.25	0.84–1.87	0.27
4th quartile	1.26	1.04–1.53	0.02	1.33	1.04–1.69	0.03	1.10	0.78–1.53	0.59

O.R.: Odds ratio; C.I.: 95% Confidence interval; MELD: Model for End-Stage Liver Disease

^*Multivariable logistic model included variables listed in the table.

^**Score not available for the majority of patients during the pre-MELD period

^***Time between transplant: quartile 1 = 1–11 days, quartile 2 = 12–159 days, quartile 3 = 160 – 918 days, quartile 4 = 919 – 7281 days

^****Cold ischemia: quartile 1 = 4.5–1.40 hours, quartile 2 = 6.0–8.1 hours, quartile 3 = 8.2–9.3 hours, quartile 4 = 9.4–70.4 hours

^*****Warm ischemia: quartile 1 = 0–35 minutes, quartile 2 = 36–44 minutes, quartile 3=45–49 minutes, quartile 4 = 50–237 minutes