Skip to main content
. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Neurobiol Learn Mem. 2009 Jun 14;92(3):429–438. doi: 10.1016/j.nlm.2009.06.005

Figure 3.

Figure 3

Effects of galanin on dentate physiology in-vivo. (A) No significant differences in the PS amplitudes across stimulus levels was found; (B) Saline, galanin 2–11 or galanin 1–29 had no significant effect on PP responses; (C) High-frequency afferent stimulation (HFS) resulted in prolonged synaptic enhancement of PS amplitudes in the DG in saline-treated (□), but not in galanin 2–11-treated (▲) or galanin 1–29-treated (●) rats at 30 min (F(2,21)=3.55, p=0.0.046; n=6–10) and 60 min (F(2,21)=3.94, p=0.404; post HFS (saline vs galanin 2–11 and galanin 1–29). Pre-HFS values were not different between groups (F(2,21)=0.39, p=0.67; n=6–10) and at 10 min post HFS (F(2,21)=2.62, p=0.0.096; n=6–10), 60 min (F(2,21)=3.94, p=0.404. Each group represents the mean ± s.e.m. *, p < 0.05 (ANOVA). (D) Representative samples waveforms were characterized by a relatively fast negative-going population spike (PS) superimposed on the positive-going field EPSP/IPSP complex. At baseline, superimposed recording during pretreatment (black) and post treatment (red) show no differences in the amplitude of the PS in galanin 2–11 and galanin 1–29 treated rats. Samples of recordings at 60 minutes after HFS indicate a significant enhancement only in the control group whereas galanin 2–11 and galanin 1–29 impaired LTP maintenance.