Table 3.

Association of breast cancer risk with the c.-2265C>T SNP in the BRCA1 gene, on subjects recruited in the Hong Kong Chinese and in the Shanghai Breast Cancer Study.

	Hong Kong				Shanghai				Test of heterogeneity	Combined analysis††
c.-2265C>T	Cases (%)	Controls (%)	p-value*	OR (95% CI)*	Cases (%)	Controls (%)	p-value**	OR (95% CI)**	p-value	p-value	OR (95% CI)
	All subjectsa
	(368 cases, 375 controls)				(1109 cases, 1185 controls)
CC	143 (38.9%)	109 (29.1%)		1.00 (reference)	469 (42.3%)	457 (38.6%)		1.00 (reference)			1.00 (reference)
CT/TT	225 (61.1%)	266 (70.9%)	0.005	0.64 (0.47–0.88)	640 (57.7%)	728 (61.4%)	0.054	0.85 (0.71–1.00)	0.11	0.003	0.80 (0.69–0.93)
HWE†	p=0.23	p=0.22			p=0.07	p=0.55
	Subjects without family history of breast cancer
	(333 cases, 363controls)				(1070 cases, 1156 controls)
CC	129 (38.7%)	107 (29.5%)		1.00 (reference)	459 (42.9%)	442 (38.2%)		1.00 (reference)			1.00 (reference)
CT/TT	204 (61.3%)	256 (70.5%)	0.01	0.66 (0.48–0.91)	611 (57.1%)	714 (61.8%)	0.019	0.81 (0.69–0.97)	0.23	0.001	0.78 (0.68–0.91)
	Subjects ≥ 45 yrs at first diagnosis and without family history of breast cancer
	(166 cases, 166 controls)				(637 cases, 678 controls)
CC	71 (42.8%)	46 (27.7%)		1.00 (reference)	281 (44.1%)	265 (39.1%)		1.00 (reference)			1.00 (reference)
CT/TT	95 (57.2%)	120 (72.3%)	0.006	0.51 (0.32–0.81)	356 (55.9%)	413 (60.9%)	0.039	0.79 (0.63–0.99)	0.08	0.004	0.75 (0.61–0.91)

^*p-values were obtained by Chi-square test, df=1.

^**Logistic regression analysis adjusted for age, education, body mass index, waist-to-hip ratio, physical activity, menopausal status, age at menarche, and age at first live birth.

^†p-values for HWE were calculated by Chi-square test, df=1.

^††Combined analysis was performed using Mentel-Hanzel test.

^aOverall cases and control subjects successfully genotyped.