Table 1.
Delineation of MDRs and MARs based on recurrent abnormalities identified in >5% of patients. In regions smaller than 20 Mb were listed the CIG (cancer implicated genes) expressed in at least 50% of WM patients. CIG include tumor suppressor genes and/or genes with inactivated mutations already described.
| Cytoband | Chromsome position (bp) | Loss (%) | Gain (%) | Size (Mb) | Expressed CIG |
|---|---|---|---|---|---|
| 3q13.3-q28 | chr3: 121238508-199379625 | 9.5 | 78.1 | ||
| 4q13.1-q35.2 | chr4: 65598026-191173837 | 11.9 | 125.6 | ||
| 6p12.2-p25 | chr6: 1-39874314 | 16.6 | 39.8 | ||
| 6q16.1 | chr6: 93266833-97766491 | 33.3 | 4.5 | MANEA | |
| 6q21-q22.1 | chr6: 105811723-107183767 | 38.1 | 1.4 | PRDM1, AIM1 | |
| 6q23 | chr6: 138093510-141518652 | 38.1 | 3.4 | TNFAIP3 | |
| 6q25.2-q25.3 | chr6: 155012960-159967461 | 33.3 | 4.9 | No CIG | |
| 7q22.1-q22.2 | chr7: 99534923-103321939 | 7.1 | 3.8 | STAG3, CUTL1 | |
| 8p | chr8: 1-43647063 | 7.1 | 43.6 | ||
| 8q | chr8: 76726872-136133311 | 9.5 | 59.4 | ||
| 11q22-q23.3 | chr11: 102986825-117384510 | 7.1 | 14.4 | ATM, DDX10, POU2AF1, SDHD, KIAA0999 | |
| 11q23.2-q24 | chr11: 121042811- 128566270 | 7.1 | 7.5 | FLI1 | |
| 13q14 | chr13: 49414571-50454033 | 9.5 | 1.0 | MIRN15a, MIRN16-1* | |
| 17p11.2-p13.3 | chr17: 1-17570789 | 7.1 | 17.5 | NXN, SKIP, KIAA0664, ITGAE, MINK1, ZNF232, USP6, CENTB1, TNK1, TP53, PER1, PIK3R5, DNAH9, MAP2K4, NCOR1, COPS3 | |
| 18 | chr18: 16793910-58926021 | 16.6 | 42.1 | ||
| Xq27.1-q28 | chrX: 149024400-154582473 | 9.5 | 5.6 | BGN, IRAK1, FLNA, F8, MTCP1, BRCC3 |
*
No CIG were found in 13q14, but microRNAs with proposed cancer implicated function were identified. MDRs: minimal deleted regions; MARs: minimal amplified regions.