Skip to main content
. Author manuscript; available in PMC: 2010 Aug 21.
Published in final edited form as: Biochem Biophys Res Commun. 2009 Jun 10;386(2):322–326. doi: 10.1016/j.bbrc.2009.06.026

Figure 1.

Figure 1

Minocycline protects cortical neurons from iron. Bars represent mean (± S.E.M, n = 6-12/condition) percentage lactate dehydrogenase (LDH) release (A) and malondialdehyde (MDA) levels (B) after 24 hour treatment with 10 μM ferrous sulfate (Fe) alone or with indicated concentrations (μM) of minocycline (MN). LDH values are scaled to that in cultures treated with 10 μM ferrous sulfate, which produces near-100% neuronal death, after subtraction of mean LDH in sister cultures subjected to wash and medium exchange only (SW, sham wash), in order to yield the LDH signal specific for neuronal injury. ***P<0.001. v. ferrous sulfate alone, Bonferroni multiple comparisons test.