Table 2.

Response to treatment

	Sertraline	Placebo	P
A1C levels (%)
Baseline	10.0 ± 1.8	9.7 ± 1.6	NS
6 months	8.0 ± 1.4	8.8 ± 1.9	<0.01
P	<0.001	<0.01
Systolic blood pressure (mmHg)
Baseline	137 ± 13	137 ± 14	NS
6 months	122 ± 15	131 ± 14	=0.003
P	<10−5	=0.01
Diastolic blood pressure (mmHg)
Baseline	73 ± 9	75 ± 12	NS
6 months	72 ± 10	72 ± 11	NS
P	NS	NS
LDL cholesterol concentration (mg/dl)
Baseline	101 ± 29	99 ± 34	NS
6 months	91 ± 28	93 ± 30	NS
P	NS	NS
Weight (lbs)
Baseline	181.6 ± 40.0	188.1 ± 61.7†	NS
6 months	181.5 ± 40.2	188.7 ± 58.8†	NS
P	NS	NS
HAM-D scores*
Baseline	19 ± 5	20 ± 6	NS
6 months	11 ± 6	13 ± 8	NS
P	<0.001	<0.001
Pain scale
Baseline	6 ± 2	6 ± 2	NS
6 months	4 ± 3	4 ± 3	NS
P	<0.001	=0.01

Data are means ± SD.

*Depression score: 0–7, none; 8–13, mild; 14–18, moderate; 19–22, severe; >22, very severe.

†n = 43 (one patient in wheelchair and weight not measured). NS, nonsignificant (P > 0.05).